ABSTRACT
Objective To research the effect of the baicalin to the expression of interferon(IFN)-α and IFN-β in the BALB/c mouse infected by respiratory syncytial virus(RSV),and discussed the antiviral of mechanism.Methods To establish the BALB/c mouse model of RSV,the effects of IFN-α and IFN-β in the BALB/c mouse infected by RSV were detected by ELISA.Results The IFN-α and IFN-β in the BALB/c mouse infected by RSV could be evaluated significantly by Baicalin.Conclusion The Baicalin regulates the level of IFN in the BALB/c mouse infected by RSV.
ABSTRACT
Objective To study the respiratory tract virus infection in dengue fever patients in Guangzhou. Methods Totally 280 patients with dengue fever in 2014 and 32 patients from May to December 2015 were select-ed as group A and group B respectively. The distribution of clinical symptoms and signs ,age and onset time of the 2 groups were compared. Simultaneously ,other respiratory viruses in all patients were detected. Results In group B,the incidence of fever,bone pain,myalgia/body weight fatigue,anorexia,diarrhea,rash diagnosed and hemorrhage was higher than that in group A. The incidence difference of headache,bone pain,myalgia/body weight fatigue,anorexia and rash in 2 groups indicated no statistical significance(P > 0.05)but the incidence of anorexia was significantly different(P 0.05)except that of 51 ~65 years in 2 groups(P 0.05). Conclusions The incidence of dengue fever is different in Guangzhou area at different time. The patients present different clinical symptoms and signs. Analysis of different pathogenic characteristics provides important basis for clinical treatment of dengue fever.